Rho‐GTP Exchange Factors (GEFs) mediating Ca2+ sensitization in smooth muscle
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چکیده
منابع مشابه
Ca2+ sensitization of smooth muscle contractility induced by ruthenium red.
The effects of ruthenium red (RuR) on contractility were examined in skinned fibers of guinea pig smooth muscles, where sarcoplasmic reticulum function was destroyed by treatment with A-23187. Contractions of skinned fibers of the urinary bladder were enhanced by RuR in a concentration-dependent manner (EC50 = 60 μM at pCa 6.0). The magnitude of contraction at pCa 6.0 was increased to 320% of c...
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Ca(2+) ion is a universal intracellular messenger that regulates numerous biological functions. In smooth muscle, Ca(2+) with calmodulin activates myosin light chain (MLC) kinase to initiate a rapid MLC phosphorylation and contraction. To test the hypothesis that regulation of MLC phosphatase is involved in the rapid development of MLC phosphorylation and contraction during Ca(2+) transient, we...
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Airway smooth muscle tone is ultimately generated by phosphorylation of myosin light chain, which is regulated by the balance between concentrations of Ca2+ and sensitivity to Ca2+ in the cytosolic side. The former is due to the Ca2+ influx passing through ion channels (Ca2+ dynamics), leading to activation of myosin light chain kinase, and the latter is due to Rho-kinase (Ca2+ sensitization), ...
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Over the past decade, an increasing appreciation has developed for the role of small GTP-binding proteins (GTPases) as critical molecular switches. Small GTPases function as important regulators of multiple cellular processes by transducing signals from extracellular stimuli to intracellular effector pathways. The three primary members of the Rho family of GTPases include Rho, Rac, and Cdc42, w...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a105-a